It is possible to underestimate the importance of setting in fiction, but it is not possible to have no setting whatsoever in fiction . Behavior only occurs in a setting.
In his book, Into the Wild, John Krakauer follows his subject, Christopher McCandless, into the wilds of Alaska. The setting relative to human interaction is as spare, I guess, as it gets in that work, unless of course the subject of a work is other than human.
Our characters are shaped by their context. It is important to remember that, to remember that setting influences our behaviors. We have a fascination for what other people do within a particular context. How we act. How we think. How we interact. How our setting influences our behavior.